Product Description
PTMA polyclonal Antibody | BS60817 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Prothymosinα (PTα) is a nuclear protein that iswidely expressed inmammalian tissues, including kidney, liver,spleen, normal lymphocytes, human T cell leukemia virus-infected T cells andmyeloma cells. The human PTα genemaps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlatesto transcription sites. PTα is a chromatin-remodeling protein that wasinitiallythought to mediate T lymphocyte maturation, butsubsequently has been shown to be involved in cellcycle progression, proliferation and cell differentiation. PTα isthought to be transported into the nucleus bythe karyopherin β1-Rch-1 complex,where it associates with Histones H2A, H2B, H3 and H4. Also, PTα is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin α-phosphorylating kinase (PTαK) in amitogen activating pathway. The amino terminus of PTα iscleaved to produce a secreted, biologically active peptide thymosin α1,whichmay be used as an immunomodulatorin cancer patients and patients with chronic active hepatitis, or as an immunoen hancer of vaccinesin immunocompromised individuals.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PTMA polyclonal Antibody detects endogenous levels of PTMA protein.
Molecular Weight: ~ 12 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Prothymosin alpha; Cleaved into the following 2 chains; Prothymosin alpha, N-terminally processed; Thymosin alpha-1; PTMA; TMSA
Immunogen: A synthetic peptide corresponding to residues in Human PTMA.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A