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Product Description
Rho D polyclonal Antibody | BS5898 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC IP
Application Range: WB: 1:500~1:1000 ICC: 1:50~1:200 IP: 1:50~1:200
Background: Upon activation, the small GTPase Rho D (also designated RhoHP1 and ARHD) contributes to rearrangement of the actin cytoskeleton and cell surface and also governs endosome motility and distribution. The effects of Rho D antagonize those of its family member, Rho A, by dissasembling actin stress fibers normally enhanced by Rho A. Additionally, Rho D disengages focal adhesions, resulting in retardation of cell migration. Accordingly, transfection of a constitutively active form of Rho D (designated Rho D G26V) reverses the invasive phenotype of Gαolf induced cells, implying the possiblity of a therapeutic use for activated Rho D in counteracting tumor metastasis.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Rho D polyclonal Antibody detects endogenous levels of Rho D protein.
Molecular Weight: ~ 23 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RhoHP1; RHOD; ARHD
Immunogen: Synthetic peptide, corresponding to amino acids 156-201 of Human Rho D.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
