Product Description
CREB3 polyclonal Antibody | BS6947 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: HCF-1 is a cellular protein required by VP16, a viral tegument, to activate the herpes simplex virus (HSV) immediate-early genes. In addition to playing an essential role in cell proliferation, HCF-1 also functions as a coactivator for the basic leucine zipper transcription factor LZIP (also designated Luman or CREB3 . Both LZIP and VP16 contain the binding motif (D/E) HXY (S/A), which is recognized by an amino terminal beta-propeller domain in HCF-1. LZIP, a member of the ATF/CREB family, is a type II membrane-associated glycoprotein that is ubiquitously expressed in adult and fetal tissues. LZIP associates with the endoplasmic reticulum, where it sequesters most of the cellular HCF-1. Like other CREB/ATF family members, LZIP activates transcription from genes containing cyclic AMP response elements (CREs) . LZIP activity is repressed by the inhibitory interaction of HCLP-1 .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CREB3 polyclonal Antibody detects endogenous levels of CREB3 protein.
Molecular Weight: ~ 44 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cyclic AMP-responsive element-binding protein 3; CREB-3; cAMP-responsive element-binding protein 3; Leucine zipper protein; Luman; Transcription factor LZIP-alpha; CREB3; LZIP
Immunogen: Recombinant full length Human CREB3.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: