Product Description
KDM5B polyclonal Antibody | BS70906 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IF
Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200
Background: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: KDM5B polyclonal Antibody detects endogenous levels of KDM5B protein.
Molecular Weight: ~ 176 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Lysine-specific demethylase 5B; Cancer/testis antigen 31; CT31; PLU-1; RBP2-H1; JARID1B; PLU1; RBBP2H1
Immunogen: Recombinant protein of human KDM5B.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Vesicle Trafficking presynaptic signaling,