Product Description
PAR4 (R68) polyclonal Antibody | BS3238 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IF
Application Range: WB: 1:500~1:1000 IF: 1:50~1:200
Background: Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2, PAR-3 and PAR-4 compose a distinct class of G protein-coupled rec-eptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor. Cytokines including TNF-α and IL-1β increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PAR-4 (R68) polyclonal Antibody detects endogenous levels of PAR-4 protein.
Molecular Weight: ~ 41 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Proteinase-activated receptor 4; PAR-4; Coagulation factor II receptor-like 3; Thrombin receptor-like 3; F2RL3; PAR4
Immunogen: Synthetic peptide, corresponding to amino acids 34-87 of Human PAR4.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A