Product Description
PLOD2 polyclonal Antibody | BS8602 | Bioworld
Host: Rabbit
Reactivity: Human,Rat
Application: WB IF
Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:100
Background: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PLOD2 polyclonal Antibody detects endogenous levels of PLOD2 protein.
Molecular Weight: ~ 85kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Lysyl hydroxylase 2; LH2; PLOD2
Immunogen: Recombinant full length Human PLOD2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: