Product Description
TPP2 polyclonal Antibody | BS8204 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: Tripeptidyl peptidase II (TPPII), is a large intracellular serine exopeptidase with a subtilisin active site . TPPII protein is larger than the 26S proteasome and has a rod-shaped, dynamic supramolecular structure . TPPII is highly conserved among species and it sequentially removes tripeptides from the free amino-terminus of short peptides. TPPII has enhanced activity in proteosome inhibitor-adapted cells and degrades polypeptides by exo- as well as predominantly trypsin-like endoproteolytic cleavage. TPPII participates in the apoptotic pathway triggered by Shigella and is also involved in apoptosis induced by ATP and the protein kinase inhibitor staurosporine . Overexpression of TPPII is sufficient to prevent accumulation of polyubiquitinated proteins and partially restores peptide loading of MHC molecules . TPPII is able to compromise proteosome activity and normalize the rate of intracellular protein breakdown, which is required for normal cellular function and viability.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TPP2 polyclonal Antibody detects endogenous levels of TPP2 protein.
Molecular Weight: ~ 138 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Tripeptidyl-peptidase 2; TPP-2; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II; TPP-II; TPP2
Immunogen: Recombinant full length Human TPP2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: