Product Description
RNF40 polyclonal Antibody | BS91173 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IP IHC
Application Range: WB:1:1,000-1:2,000 IP:1:10-1:50 IHC:1:50
Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1) . H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) . It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Specificity: RNF40 polyclonal Antibody detects endogenous levels of RNF40 protein.
Molecular Weight: 114 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: BRE1-B, RBP95, RNF40, BRE1B, KIAA0661, 95 kDa retinoblastoma associated protein, 95 kDa retinoblastoma protein binding protein, 95 kDa retinoblastoma-associated protein, BRE 1B, BRE1 B, BRE1 E3 ubiquitin ligase homolog B, BRE1-B, BRE1B, BRE1B, DKFZp686K191, E3 ubiquitin protein ligase BRE1B, E3 ubiquitin-protein ligase BRE1B, KIAA0661, MGC13051, Rb associated protein, RBP 95, RBP95, RING finger protein 40, Ring finger protein 40 E3 ubiquitin protein ligase, RNF 40, Rnf40, STARING Antibody
Immunogen: Recombinant protein within human RNF40 aa 200-400.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A purified.
Pathway: