Quick view Biovision | Guanfacine hydrochloride | B2990 Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand... MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Biovision | Poly(I:C) | B2989 Poly(I:C) is a double-stranded homopolymer of polyinosinic acid and polycytidylic acid. Transfection of Poly(I:C) (1 μg/ml) into NIT 1 cells has been used as a model of intracellular double-stranded... MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Biovision | 27-Hydroxycholesterol | B2988 27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and... MSRP: Was: Now: £542 - £1,656 Choose Options Compare
Quick view Biovision | Desipramine hydrochloride | B2987 Desipramine HCl is a tricyclic antidepressant that is a selective inhibitor of norepinephrine transporter with Ki values of 4 nM, 61 nM and 78.72 μM for Norepinephrine Transporter (NET), Serotonin... MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Biovision | LDN-193189 dihydrochloride | B2986 LDN-193189 inhibits transcriptional activity of the (Bone Morphogenetic Protein) BMP type I receptors known as activin receptor-like kinases (ALKs). It inhibits ALK2 and ALK3 with IC₅₀ values of 5 nM... MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Biovision | Tasimelteon | B2985 Tasimelteon is a potent Dual Melatonin Receptor Agonist (DMRA). It is used to treat non-24-hour sleep-wake disorder. The Ki values for binding affinity at melatonin receptors MT1 and MT2 receptor are... MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Biovision | Ripasudil hydrochloride dihydrate | B2984 Ripasudil (K-115) is a potent inhibitor of Rho kinase (ROCK), with IC₅₀ values of 19 and 51 nM for ROCK-2 and ROCK-1, respectively. Ripasudil (10 μM) induces cytoskeletal changes, including... MSRP: Was: Now: £478 - £1,394 Choose Options Compare
Quick view Biovision | Vigabatrin | B2983 Vigabatrin (VGB) is a structural analogue of gamma-aminobutyric acid (GABA) that irreversibly inhibits GABA-transaminase (GABA-T). It inhibits the catabolism of GABA by GABA transaminase and... MSRP: Was: Now: £508 - £1,542 Choose Options Compare
Quick view Biovision | Cystamine dihydrochloride | B2982 Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s... MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Biovision | NQTrp | B2981 NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12... MSRP: Was: Now: £478 - £1,410 Choose Options Compare
Quick view Biovision | AC-186 | B2980 AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated... MSRP: Was: Now: £410 - £1,134 Choose Options Compare
Quick view Biovision | TGN-020 | B2979 TGN-020 is an inhibitor of aquaporin 4 (AQP4), the most abundant water channel in brain. It inhibits AQP4 inhibitor with an IC₅₀ of 3 μM in vitro. Pretreatment with the AQP4 inhibitor TGN-020... MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Biovision | AMTB hydrochloride | B2978 AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the... MSRP: Was: Now: £674 - £2,198 Choose Options Compare
Quick view Biovision | TCS 5861528 | B2977 TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values... MSRP: Was: Now: £756 - £2,508 Choose Options Compare
Quick view Biovision | ASP7663 | B2976 ASP7663 is a selective transient receptor potential ankyrin 1 (TRPA1) activator. It activates human, rat and mouse TRPA1 receptors with EC₅₀ values of 510 nM, 540 nM and 500 nM, respectively. It... MSRP: Was: Now: £542 - £1,656 Choose Options Compare
Quick view Biovision | R-59-022 | B2975 R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and... MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Biovision | JNJ-17203212 | B2974 JNJ-17203212 is a reversible and potent antagonist of transient receptor potential vanilloid 1 (TRPV1) with pKi values of 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively. It Inhibits... MSRP: Was: Now: £854 - £2,916 Choose Options Compare
Quick view Biovision | A-839977 | B2973 A-839977 is a potent antagonist of the purinergic receptor P2X subtype 7 (P2X7). A-839977 potently blocks BzATP-induced calcium influx at recombinant human, rat and mouse P2X7 receptors with IC₅₀... MSRP: Was: Now: £576 - £1,788 Choose Options Compare
Quick view Biovision | JNJ-47965567 | B2972 JNJ-47965567 is a potent and selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux. JNJ-47965567... MSRP: Was: Now: £576 - £1,788 Choose Options Compare
Quick view Biovision | CA-074 | B2971 CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC₅₀ of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It... MSRP: Was: Now: £640 - £2,066 Choose Options Compare
Quick view Biovision | 666-15 | B2970 666-15 is a potent and selective inhibitor of cyclic adenosine monophosphate response element binding protein (CREB)-mediated gene transcription with an IC₅₀ of 81 nM. The IC₅₀ values for inhibiting... MSRP: Was: Now: £478 - £1,394 Choose Options Compare
Quick view Biovision | COG133 | B2969 COG 133 is a fragment of Apolipoprotein E (APOE) that mimics the anti-inflammatory and neuroprotective effects of the intact apoE protein. It functions through the low-density lipoprotein... MSRP: Was: Now: £462 - £1,346 Choose Options Compare
Quick view Biovision | Probucol | B2968 Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. The use... MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Biovision | Gramicidin A | B2967 Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from Bacillus brevis. Gramicidin A is a linear channel-forming ionophore pentadecapeptide that forms a... MSRP: Was: Now: £508 - £1,542 Choose Options Compare
Quick view Biovision | Anidulafungin | B2966 Anidulafungin is an echinocandin antifungal drug. It inhibits (1→3)-β-D-glucan synthase which is required for synthesis of the fungal cell wall. It shows potent in vitro activity against Aspergillus... MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Biovision | PLX5622 (free base) | B2965 PLX5622 is an inhibitor of colony-stimulating factor 1 receptor (CSF1R) tyrosine kinase with a Ki of 5.9 nM. It causes sustained and specific elimination of microglia. As a result of microglial... MSRP: Was: Now: £738 - £2,444 Choose Options Compare
Quick view Biovision | Astragalin | B2964 Astragalin is a flavonoid isolated from leaves of persimmon, green tea seeds, wine and American pokeweed. It shows anti-inflammatory and anti-oxidant activity. It dose-dependently (20-80 µg/ml)... MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Biovision | Benserazide hydrochloride | B2963 Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It blocks the conversion of L-DOPA to dopamine by AADC in the peripheral... MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Biovision | CAY10505 | B2962 CAY10505 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), selectively inhibiting the γ isoform with an IC₅₀ of 30 nM. It inhibits the α, β, and δ isoforms of PI3K with IC₅₀ values of 0.94,... MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Biovision | Boceprevir | B2961 Boceprevir is a protease inhibitor that binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication,... MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Biovision | Allicin | B2960 Allicin is a natural product isolated from garlic (Allium sativum) that exhibits many biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities. Allicin (5-10... MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Biovision | Thiamet G | B2959 Thiamet G is a potent and selective inhibitor of O-GlcNAcase with a Ki value of 21 nM. It increases cellular O-GlcNAc-modified protein levels with an EC₅₀ of 30 nM and blocks phosphorylation of tau... MSRP: Was: Now: £576 - £1,788 Choose Options Compare
Quick view Biovision | Importazole | B2958 Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged... MSRP: Was: Now: £508 - £1,542 Choose Options Compare
Quick view Biovision | Daltroban | B2957 Daltroban is an antagonist of thromboxane A2 receptor. Daltroban (20 mg/kg per h i.v.) protects the myocardium from ischaemic injury by preventing ischaemia-induced leukocytosis in cats. Infusion (1... MSRP: Was: Now: £478 - £1,394 Choose Options Compare
Quick view Biovision | Aphidicolin | B2956 Aphidicolin is a natural tetracyclic diterpene antibiotic which shows antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication,... MSRP: Was: Now: £526 - £1,606 Choose Options Compare
Quick view Biovision | Flubendazole | B2955 Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection... MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Biovision | Valbenazine | B2954 Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2). VMAT2 plays an important role in the packaging of monoamines into presynaptic vesicles. Valbenazine shows Ki values of 110... MSRP: Was: Now: £444 - £1,262 Choose Options Compare
Quick view Biovision | Wogonoside | B2953 Wogonoside is a flavonoid with antioxidant, anti-cancer and anti-angiogenic activity. Wogonoside inhibits the growth of U937 and HL-60 cells cells. It arrests the cell cycle at the G0/G1 phase and... MSRP: Was: Now: £478 - £1,410 Choose Options Compare
Quick view Biovision | GSK 1016790A | B2952 GSK1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist that elicits calcium influx in HEK cells expressing mouse or human transient TRPV4 with EC₅₀ values of 18 and 2.1 nM,... MSRP: Was: Now: £772 - £2,590 Choose Options Compare
Quick view Biovision | Tryptanthrin | B2951 Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It... MSRP: Was: Now: £542 - £1,656 Choose Options Compare
Quick view Biovision | ONC212 | B2950 ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines... MSRP: Was: Now: £410 - £1,134 Choose Options Compare
Quick view Biovision | Valnemulin hydrochloride | B2949 Valnemulin is a pleuromutilin antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit of bacteria. It is used to treat swine diseases including Brachyspira hyodysenteriae... MSRP: Was: Now: £410 - £1,134 Choose Options Compare
Quick view Biovision | Destruxin B | B2948 Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. It shows insecticidal and anti-cancer properties. It induces a concentration-dependent antiproliferative... MSRP: Was: Now: £1,180 - £1,788 Choose Options Compare
Quick view Biovision | Destruxin A | B2947 Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. Destruxins show insecticidal, anti-viral, and phytotoxic properties. Destruxin A suppresses the Drosophila... MSRP: Was: Now: £1,180 - £1,788 Choose Options Compare
Quick view Biovision | Sanguinarine | B2946 Sanguinarine is a benzylisoquinoline alkaloid that inhibits PP2C and shows selectivity for PP2C over PP1, PP2A, and PP2B in vitro. It inhibits MKP-1 with an IC₅₀ of 10 μM and shows selectivity for... MSRP: Was: Now: £380 - £1,002 Choose Options Compare
Quick view Biovision | Demethoxycurcumin | B2945 Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in... MSRP: Was: Now: £380 - £1,002 Choose Options Compare
Quick view Biovision | Bisdemethoxycurcumin | B2944 Bisdemethoxycurcumin is a curcumin analogue with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in... MSRP: Was: Now: £364 - £968 Choose Options Compare
Quick view Biovision | GNE-9605 | B2943 GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC₅₀ of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2... MSRP: Was: Now: £380 - £1,002 Choose Options Compare
Quick view Biovision | GNE-0877 | B2942 GNE-0877 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with a Ki of 0.7 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-0877 inhibits LRRK2... MSRP: Was: Now: £444 - £1,262 Choose Options Compare
Quick view Biovision | CZC-25146 | B2941 CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant... MSRP: Was: Now: £640 - £2,048 Choose Options Compare
Quick view Biovision | LRRK2-IN-1 | B2940 LRRK2-IN-1 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2). Mutations in LRRK2 are associated with Parkinson's disease. LRRK2-IN-1 inhibits wild-type and G2019S mutant LRRK2 with IC₅₀... MSRP: Was: Now: £380 - £1,002 Choose Options Compare
Quick view Biovision | IQA | B2939 IQA is an indoloquinazoline derivative that acts as a selective and reversible casein kinase (CK2) inhibitor with an IC₅₀ of 390 nM with 100 µM ATP. It inhibits CK2 in an ATP- and GTP-competitive... MSRP: Was: Now: £542 - £1,640 Choose Options Compare
Quick view Details Biovision | Guanfacine hydrochloride | B2990 MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Details Biovision | 27-Hydroxycholesterol | B2988 MSRP: Was: Now: £542 - £1,656 Choose Options Compare
Quick view Details Biovision | Desipramine hydrochloride | B2987 MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Details Biovision | LDN-193189 dihydrochloride | B2986 MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Details Biovision | Tasimelteon | B2985 MSRP: Was: Now: £364 - £934 Choose Options Compare
Quick view Details Biovision | Ripasudil hydrochloride dihydrate | B2984 MSRP: Was: Now: £478 - £1,394 Choose Options Compare
Quick view Details Biovision | Vigabatrin | B2983 MSRP: Was: Now: £508 - £1,542 Choose Options Compare
Quick view Details Biovision | Cystamine dihydrochloride | B2982 MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Details Biovision | AMTB hydrochloride | B2978 MSRP: Was: Now: £674 - £2,198 Choose Options Compare
Quick view Details Biovision | TCS 5861528 | B2977 MSRP: Was: Now: £756 - £2,508 Choose Options Compare
Quick view Details Biovision | JNJ-17203212 | B2974 MSRP: Was: Now: £854 - £2,916 Choose Options Compare
Quick view Details Biovision | JNJ-47965567 | B2972 MSRP: Was: Now: £576 - £1,788 Choose Options Compare
Quick view Details Biovision | Gramicidin A | B2967 MSRP: Was: Now: £508 - £1,542 Choose Options Compare
Quick view Details Biovision | Anidulafungin | B2966 MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Details Biovision | PLX5622 (free base) | B2965 MSRP: Was: Now: £738 - £2,444 Choose Options Compare
Quick view Details Biovision | Astragalin | B2964 MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Details Biovision | Benserazide hydrochloride | B2963 MSRP: Was: Now: £364 - £952 Choose Options Compare
Quick view Details Biovision | Boceprevir | B2961 MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Details Biovision | Thiamet G | B2959 MSRP: Was: Now: £576 - £1,788 Choose Options Compare
Quick view Details Biovision | Importazole | B2958 MSRP: Was: Now: £508 - £1,542 Choose Options Compare
Quick view Details Biovision | Daltroban | B2957 MSRP: Was: Now: £478 - £1,394 Choose Options Compare
Quick view Details Biovision | Aphidicolin | B2956 MSRP: Was: Now: £526 - £1,606 Choose Options Compare
Quick view Details Biovision | Flubendazole | B2955 MSRP: Was: Now: £380 - £1,018 Choose Options Compare
Quick view Details Biovision | Valbenazine | B2954 MSRP: Was: Now: £444 - £1,262 Choose Options Compare
Quick view Details Biovision | Wogonoside | B2953 MSRP: Was: Now: £478 - £1,410 Choose Options Compare
Quick view Details Biovision | GSK 1016790A | B2952 MSRP: Was: Now: £772 - £2,590 Choose Options Compare
Quick view Details Biovision | Tryptanthrin | B2951 MSRP: Was: Now: £542 - £1,656 Choose Options Compare
Quick view Details Biovision | Valnemulin hydrochloride | B2949 MSRP: Was: Now: £410 - £1,134 Choose Options Compare
Quick view Details Biovision | Destruxin B | B2948 MSRP: Was: Now: £1,180 - £1,788 Choose Options Compare
Quick view Details Biovision | Destruxin A | B2947 MSRP: Was: Now: £1,180 - £1,788 Choose Options Compare
Quick view Details Biovision | Sanguinarine | B2946 MSRP: Was: Now: £380 - £1,002 Choose Options Compare
Quick view Details Biovision | Demethoxycurcumin | B2945 MSRP: Was: Now: £380 - £1,002 Choose Options Compare
Quick view Details Biovision | Bisdemethoxycurcumin | B2944 MSRP: Was: Now: £364 - £968 Choose Options Compare
Quick view Details Biovision | CZC-25146 | B2941 MSRP: Was: Now: £640 - £2,048 Choose Options Compare
Quick view Details Biovision | LRRK2-IN-1 | B2940 MSRP: Was: Now: £380 - £1,002 Choose Options Compare