Biovision

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Biovision | Erythromycin | 9619

Erythromycin is a macrolide antibiotic with a target spectrum similar to penicillin. It inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of...

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Biovision | Orlistat | B1020

Orlistat is a cell-permeable, selective, and competitive lipase inhibitor (IC₅₀ = 0.15 µM). Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible...

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Biovision | Pimobendan | 9676

Pimobendan is a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects. Pimobendan has been studied for treating heart failure...

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Biovision | Tranilast | 1876

Cell-permeable. A potent angiogenesis inhibitor. Inhibits VEGF-induced angiogenetic activities. Displays anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine...

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Biovision | Bimatoprost | B1318

Bimatoprost is a synthetic prostamide, structurally related to prostaglandin F2α. Bimatoprost is an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity in bovine and human...

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Biovision | Felbamate | B2004

Felbamate is an antiepileptic drug that is effective against seizures in a variety of animal models. It displays inhibitory effects at NMDA and GABAA receptors and at voltage-gated channels.Felbamate...

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Biovision | Ellagic Acid | B1154

Ellagic acid is a potent anti-oxidant that displays anti-cancer and anti-mutagenic properties. It inhibits CK2 (casein kinase 2) selectively with IC₅₀ values of 40 nM. It moderately inhibits...

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Biovision | Imiquimod | 1698

Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of...

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Biovision | Lithocholic acid | 2187

Lithocholic acid (LCA) is a hydrophobic secondary bile acid that is primarily formed in the intestine by the bacterial 7-α dehydroxylation of chenodeoxycholic acid. Acts as a detergent to solubilize...

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Biovision | L-Ascorbic acid | 2269

Also known as Vitamin C, Ascorbic acid functions as a powerful antioxidant, particularly in regards to reactive oxygen species (ROS). It functions as an enzymatic cofactor for multiple enzymes,...

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Biovision | Verteporfin | B1583

Verteporfin is a photosensitizer used during photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. More recently,...

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Biovision | Bestatin | 1733

A potent aminopeptidase inhibitor (Ki = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A4 hydrolase. Displays antitumor and immunostimulant properties.Bestatin is a potent...

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Biovision | Tigecycline | 1956

A glycylglycine type of antibiotic derived from tetracycline. Inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the...

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Biovision | Stavudine | B2084

Stavudine is a nucleoside analog that acts as a reverse transcriptase inhibitor. Displays in vitro activity against HIV. An antiviral agent.Stavudine is a nucleoside analog that acts as a reverse...

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Biovision | Daptomycin | 2582

Daptomycin is a lipopeptide antibacterial antibiotic that exhibits rapid, concentration-dependent bactericidal activity against Gram-positive organisms in vitro. Daptomycin binds to bacterial...

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Biovision | Glimepiride | B1101

Glimepiride is a potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC₅₀ of 6.8 nM. Glimepiride displays a higher potency compared...

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Biovision | Edaravone | B2024

Edaravone is a low-molecular-weight antioxidant drug targeting peroxyl radicals among many types of reactive oxygen species. Most notably, it reduces damage due to ischemia-reperfusion injury in...

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Biovision | Artemisinin | 2519

Artemisinin is a sesquiterpene natural product originally isolated from plants of the genus Artemisia. It effectively kills malarial parasites of the genus Plasmodium (IC₅₀ = 4.0 nM). Displays...

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Biovision | Acarbose | B2104

Acarbose is an inhibitor of α-glucosidase and pancreatic α-amylase with antihyperglycemic activity. Acarbose binds to and inhibits α-glucosidase, an enteric enzyme found in the brush border of the...

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Biovision | Leflunomide | 1972

Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for...

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Biovision | Melatonin | 2488

Melatonin is an endogeneous hormone that plays a prominent role in the control of circadian rhythm. Melatonin acts as an agonist at melatonin receptors MT1 and MT2, displays immunomodulatory activity...

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Biovision | Voglibose | B2111

Voglibose is a competitive α-glucosidase inhibitor (IC₅₀ = 5.6 µM). It delays the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase,...

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Biovision | Capecitabine | 1741

A pre-prodrug of 5-fluorouracil (5-FU). After oral uptake, capecitabine is first metabolized to 5'-deoxy-5-fluorocytidine (5'-DFCR), which occurs mainly in the liver by carboxyl-esterase. The...

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Biovision | Paclitaxel | 1567

An Antitumor and antileukemic agent. Promotes assembly of microtubules and inhibits tubulin disassemblyPaclitaxel is an antitumor and antileukemic agent. Promotes assembly of microtubules and...

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Biovision | Docetaxel | 2232

An anticancer agent. Docetaxel binds to microtubules reversibly with high affinity and prevents microtubule depolymerization and disassembly in the absence of GTP. Used mainly for the treatment of...

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Biovision | Cerulenin | 1579

Antibiotic. Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of...

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Biovision | Tunicamycin | 2802

From Streptomyces lysosuperificus. Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs in the fatty acid chain. Potent inhibitor of GlcNAc phosphotransferase which...

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Biovision | Teicoplanin | 1756

Teicoplanin is a lipoglycopeptide antibiotic extracted from Actinoplanes teichomiceticus. Acts against Gram-postive bacteria including methicillin-resistant Staphylococcus aureus and Enterococcus...

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Biovision | Tildipirosin | 9673

Tildipirosin is a 16-membered macrolide antibiotic used in veterinary medicine. It inhibits protein synthesis in bacteria and blocks the production of biofilms. Tildipirosin is particularly effective...

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Biovision | Bosentan | B1857

Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Inhibits ET-1 induced contraction of isolated rat aorta and sarafotoxin S6C-induced contraction of...

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Biovision | Pentostatin | B2038

Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It...

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Biovision | Clofarabine | 2236

A purine nucleoside antimetabolite that displays anticancer activity. Clofarabine displays potent inhibitory effects on both ribonucleotide reductase and DNA polymerase. Used in pediatrics to treat a...

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Biovision | 5-Fluorouracil | B1519

5-Fluorouracil (5-FU) is an anticancer agent that gets metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits...

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Biovision | Ritonavir | B2140

Ritonavir is an orally bioavailable HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Through CYP3A4 inhibition, low doses of ritonavir can reduce the...

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Biovision | BMX-IN-1 | B1330

BMX-IN-1 is a highly selective and potent irreversible inhibitor of BMX kinase.BMX-IN-1 is a highly selective and potent irreversible inhibitor of BMX kinase.Biovision | B1330 | BMX-IN-1...

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Biovision | Chenodeoxycholic acid | 2831

Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. EC50 concentrations for activation of FXR (farnesoid X receptor)...

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Biovision | Voriconazole | B2032

Voriconazole is a triazole antifungal agent that displays potent activity against Candida, Cryptococcus and Aspergillus species. Useful for treatment of serious, invasive fungal infections...

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Biovision | VX-222 | B2207

VX-222 is a potent, non-nucleoside inhibitor of HCV polymerase (IC₅₀ = 0.94-1.2 μM). It is 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.VX-222 is a potent,...

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Biovision | Safinamide | B2022

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide also acts as a voltage-dependent...

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Biovision | GSK-1070916 | B1939

GSK-1070916 is a potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C with IC₅₀ value of 3.5 nM and 6.5 nM, respectively. Treatment of GSK-1070916 suppresses cell proliferation...

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Biovision | Abiraterone | B1607

Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nMAbiraterone (CB-7598) is a potent steroidal cytochrome P450...

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Biovision | Epalrestat | 2397

Epalrestat is an aldose reductase inhibitor (IC₅₀ = 10 nM (rat lens) and 25 nM (human placenta). It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. May be used to...

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Biovision | PLX-4720 | 2813

PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent...

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Biovision | Troglitazone | 1696

An antidiabetic thiazolidinedione (TDZ) drug with anti-inflammatory and anti-tumor activities. A potent and selective PPARɣ agonist. The EC₅₀ values for transactivation of human and murine PPARɣ in a...

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Biovision | Deforolimus | 1587

A small-molecule inhibitor of the mammalian target of rapamycin (mTOR). Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and...

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Biovision | ABT-737 | 2463

A small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. In vitro, ABT-737 binds Bcl-xL, Bcl-2 and Bcl-w with comparable high affinity, while it has over 1000-fold lower...

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Biovision | Dovitinib | B1614

Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitorDovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitorBiovision | B1614 | Dovitinib DataSheetAlternate Name/Synonyms: Dovitinib,...

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Biovision | Rivaroxaban | B1854

Rivaroxaban (BAY 59-7939), is a potent, reversible, small-molecule inhibitor of factor Xa and an antithrombotic agent.Rivaroxaban (BAY 59-7939), is a potent, reversible, small-molecule inhibitor of...

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Biovision | Gefitinib | 1589

Gefitinib was found to be a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but much weaker against ErbB-2 kinase (Ki = 870 nM) and ErbB-4 kinase (Ki = 1.1 µM). The IC₅₀ values for Gefitinib to...

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Biovision | Elacridar | 2792

Elacridar is a potent P-glycoprotein (P-gp/ABCG1) and breast cancer resistance protein (BCRP) inhibitor . GF120918 increases the bioavailability of cytotoxic anti-tumor drugs, and also leads to...

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Biovision | Crizotinib | 1934

A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at...

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Biovision | GSK461364 | 2287

A potent, selective and ATP-competitive inhibitor of Polo Like Kinase 1 (PLK1) (Ki = 2 nM). Displays >100-fold selectivity for PLK1 over PLK2 and PLK3. Shows anti-proliferative activity against...

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