Biovision

Quick view

Biovision | Exemestane | 9473

Exemestane is a potent, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM; Kinact = 26 nM). It induces aromatase degradation leading to a decrease in estrogen levels in plasma. As an androgen...

MSRP:

Was:

Now: $777 - $2,209

Choose Options Compare
Quick view

Biovision | Etoposide (100 mM) | 1043

A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma...

MSRP:

Was:

Now: $837 - $2,783

Choose Options Compare
Quick view

Biovision | Deflazacort | B2023

Deflazacort is a glucocorticoid that displays anti-inflammatory and immunosuppressive properties.Deflazacort is a glucocorticoid that displays anti-inflammatory and immunosuppressive properties...

MSRP:

Was:

Now: $718 - $1,985

Choose Options Compare
Quick view

Biovision | Cladribine | B2037

Cladribine is an adenosine deaminase inhibitor. It is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase. Cladribine...

MSRP:

Was:

Now: $718 - $1,866

Choose Options Compare
Quick view

Biovision | Chrysophanol | B2181

Chrysophenol is a natural anthraquinone derivative that displays antibacterial, antiviral, anti-inflammatory, and anticancer activities in various research models. Chrysophanol has been shown to...

MSRP:

Was:

Now: $665 - $1,582

Choose Options Compare
Quick view

Biovision | Chidamide | 2261

Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at...

MSRP:

Was:

Now: $777 - $2,237

Choose Options Compare
Quick view

Biovision | Budesonide | 2773

Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor (EC₅₀ = 12.4 nM). Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory...

MSRP:

Was:

Now: $718 - $1,866

Choose Options Compare
Quick view

Biovision | BTZ043 | B1206

BTZ043 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis (TB). It displays nanomolar bactericidal activity against...

MSRP:

Was:

Now: $949 - $2,898

Choose Options Compare
Quick view

Biovision | AVN-944 | B2230

AVN-944 is a potent inosine 5-monophosphate dehydrogenase (IMPDH) inhibitor that displays anticancer activities. AVN-944 inhibits the growth of human prostate cancer cells by inducing cell cycle...

MSRP:

Was:

Now: $1,008 - $3,129

Choose Options Compare
Quick view

Biovision | Ascomycin | 1573

Ascomycin (also known as Immunomycin) is an analog of tacrolimus with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant,...

MSRP:

Now: $1,463
Add to Cart Compare
Quick view

Biovision | AS-252424 | B1611

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM...

MSRP:

Was:

Now: $2,440 - $7,599

Choose Options Compare
Quick view

Biovision | LY2608204 | 2824

LY2608204 is a potent activator of glucokinase (GK) with EC₅₀ of 42 nM. Potential antidiabetic agent to treat type 2 diabetes.LY2608204 is a potent activator of glucokinase (GK) with EC₅₀ of 42 nM...

MSRP:

Was:

Now: $1,239 - $3,987

Choose Options Compare
Quick view

Biovision | PAC-1 | 1654

Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In...

MSRP:

Now: $865
Add to Cart Compare
Quick view

Biovision | Nocodazole | 2185

A microtubule inhibitor; inhibits mitosis. Disrupts microtubules by binding to β‑tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule...

MSRP:

Was:

Now: $718 - $1,866

Choose Options Compare
Quick view

Biovision | U-104 | 9631

U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM). It displays weaker affinity for the cytosolic isoforms, CAI and...

MSRP:

Was:

Now: $777 - $2,209

Choose Options Compare
Quick view

Biovision | M344 | 1607

An amide analog of Trichostatin A (Cat.# 1606-1) that potently Inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HDAC). Induces differentiation and inhibits...

MSRP:

Now: $980
Add to Cart Compare
Quick view

Biovision | Mitoxantrone | 1885

An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity...

MSRP:

Was:

Now: $749 - $1,925

Choose Options Compare
Quick view

Biovision | GSK343 | 2281

A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation...

MSRP:

Was:

Now: $777 - $1,985

Choose Options Compare
Quick view

Biovision | AC710 | 2884

AC710 is a potent, and selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM,1.0 nM, 1.3 nM and 1.0 nM for FLT3, KIT, PDGFRα and PDGFRβ respectively. Displays potent anticancer activity...

MSRP:

Was:

Now: $1,120 - $3,584

Choose Options Compare
Quick view

Biovision | GNF-5837 | B1339

A potent and selective pan-TRK inhibitor, suppressing the activity of TrkA and TrkB with IC50 of 8 and 12 nM, respectivelyA potent and selective pan-TRK inhibitor, suppressing the activity of TrkA...

MSRP:

Was:

Now: $777 - $2,156

Choose Options Compare
Quick view

Biovision | GSK126 | 2282

A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and...

MSRP:

Was:

Now: $777 - $1,985

Choose Options Compare
Quick view

Biovision | KW-2478 | B2188

KW-2478 is a potent non-ansamycin heat-shock protein 90 (HspP90) inhibitor (IC₅₀ = 3.8 nM). Displays potent anticancer activity.KW-2478 is a potent non-ansamycin heat-shock protein 90 (HspP90)...

MSRP:

Was:

Now: $1,180 - $3,703

Choose Options Compare
Quick view

Biovision | BAY 11-7082 | 1867

Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation...

MSRP:

Was:

Now: $980 - $3,014

Choose Options Compare
Quick view

Biovision | CID-1067700 | 2688

CID-1067700 is a potent, and competitive, Ras-related GTPase inhibitor. It binds the nucleotide binding pocket of Rab7 with a Ki value of 13 nM, preventing BODIPY-linked GTP and GDP binding with EC₅₀...

MSRP:

Was:

Now: $1,061 - $3,129

Choose Options Compare
Quick view

Biovision | TAK-733 | 2460

A potent, selective, non-ATP competitive, allosteric MEK inhibitor. TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins...

MSRP:

Was:

Now: $1,292 - $4,277

Choose Options Compare
Quick view

Biovision | (-)-Blebbistatin | 2406

Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro...

MSRP:

Was:

Now: $718 - $1,985

Choose Options Compare
Quick view

Biovision | Thapsigargin | 1558

Potent, cell permeable IP3-independent intracellular calcium releaser; Inhibits microsomal Ca2+-ATPase; Stimulates arachidonic acid metabolism in macrophages.Thapsigargin is a potent, cell permeable...

MSRP:

Now: $949
Add to Cart Compare
Quick view

Biovision | Tubacin | 1984

Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC₅₀ = 4 nM). Displays 1000-fold more selectivity for...

MSRP:

Was:

Now: $809 - $1,635

Choose Options Compare
Quick view

Biovision | RITA | 2469

RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53...

MSRP:

Was:

Now: $837 - $2,440

Choose Options Compare
Quick view

Biovision | Tenovin-1 | 9400

Tenovin-1 is a small molecule p53 activator that protects against MDM2-mediated p53 degradation. It acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Elevates levels...

MSRP:

Was:

Now: $777 - $2,209

Choose Options Compare
Quick view

Biovision | SR1001 | 1902

Cell-permeable. A high affinity synthetic ligand specific to both retinoic acid-related orphan receptors ɑ (RORɑ) and γt (RORγt). SR1001 inhibits interleukin-17 (TH17) cell differentiation and...

MSRP:

Was:

Now: $865 - $2,611

Choose Options Compare
Quick view

Biovision | Zebularine | 2225

Zebularine is a potent inhibitor of cytidine deaminase and DNA methylation; inhjbits DNA methylation by forming a covalent complex with DNA methyltransferases (DNMTs). Displays antitumor properties...

MSRP:

Was:

Now: $606 - $1,008

Choose Options Compare
Quick view

Biovision | U-73122 | B1887

U-73122 is an Inhibitor of receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction. A useful tool for probing the involvement...

MSRP:

Was:

Now: $949 - $2,898

Choose Options Compare
Quick view

Biovision | Dorsomorphin | 1686

Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the...

MSRP:

Now: $1,061
Add to Cart Compare
Quick view

Biovision | AICAR | 1687

A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with...

MSRP:

Was:

Now: $1,036 - $2,958

Choose Options Compare
Quick view

Biovision | PF-8380 | B1927

PF-8380 is a potent and specific inhibitor of Autotaxin (ATX) (IC₅₀ = 2.8 nM). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin. Autotaxin (ATX) is a...

MSRP:

Was:

Now: $777 - $2,209

Choose Options Compare
Quick view

Biovision | ZM 336372 | 1789

Cell-permeable. A potent, selective and ATP-competitive inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Displays 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38...

MSRP:

Was:

Now: $889 - $2,555

Choose Options Compare
Quick view

Biovision | Imisopasem manganese | B1061

Imisopasem manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and chemo/radioprotective activities...

MSRP:

Was:

Now: $949 - $2,898

Choose Options Compare
Quick view

Biovision | Evacetrapib | 2558

Evacetrapib is a potent, and selective CETP (cholesteryl ester transfer protein) inhibitor. It inhibits human recombinant CETP protein (IC₅₀ = 5.5 nM ) and CETP activity in human plasma (IC₅₀ = 36...

MSRP:

Was:

Now: $1,351 - $4,449

Choose Options Compare
Quick view

Biovision | CX-5461 | B2183

CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC₅₀s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect...

MSRP:

Was:

Now: $718 - $1,985

Choose Options Compare
Quick view

Biovision | JNK-IN-8 | 2729

JNK-IN-8 is a potent and irreversible JNK inhibitor that inhibits the phosphorylation of c-Jun. It inhibits JNK1, JNK2 and JNK4 with IC₅₀ values of of 4.7 nM, 18.7 nM and 1 nM, respectively.JNK-IN-8...

MSRP:

Was:

Now: $1,180 - $13,300

Choose Options Compare
Quick view

Biovision | Mitomycin C | 2713

Mitomycin C is an antitumor antibiotic isolated from Streptomyces sp. Mitomycin is activated by reduction in vivo generating oxygen radicals which produce crosslinks in DNA by alkylaion. This...

MSRP:

Was:

Now: $665 - $2,268

Choose Options Compare
Quick view

Biovision | XL888 | 2654

XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. XL888 specifically binds to Hsp90, inhibiting its...

MSRP:

Was:

Now: $837 - $2,440

Choose Options Compare
Quick view

Biovision | Mps1-IN-1 | B1603

Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitorMps1-IN-1 is a highly potent and selectibe Mpsl inhibitorBiovision | B1603 | Mps1-IN-1 DataSheetAlternate Name/Synonyms:...

MSRP:

Was:

Now: $1,351 - $4,449

Choose Options Compare
Quick view

Biovision | PYR-41 | 1925

Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation,...

MSRP:

Was:

Now: $809 - $2,328

Choose Options Compare
Quick view

Biovision | KN-62 | 2495

Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect...

MSRP:

Was:

Now: $1,008 - $3,129

Choose Options Compare
Quick view

Biovision | SGI-1776 | 2554

SGI-1776 is a potent and ATP-competitive Pim kinase inhibitor (IC₅₀’s = 7, 363, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively). SGI-1776 also inhibits FLT3 (IC₅₀ = 44 nM). Induces apoptosis in...

MSRP:

Was:

Now: $1,120 - $3,584

Choose Options Compare
Quick view

Biovision | Droxinostat | 9570

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 with IC₅₀ values of 16.9, 2.47 and 1.46 μM, respectively. Droxinostat sensitizes cells to apoptosis by decreasing c-FLIPL and c-FLIPS...

MSRP:

Was:

Now: $949 - $2,898

Choose Options Compare
Quick view

Biovision | A66 | B1654

A66 is a highly specific and selective p110α inhibitor with IC50 of 32 nM.A66 is a highly specific and selective p110α inhibitor with IC50 of 32 nM.Biovision | B1654 | A66 DataSheetAlternate...

MSRP:

Was:

Now: $1,635 - $5,075

Choose Options Compare
Quick view

Biovision | CCT128930 | B1763

CCT128930 is a potent, selective, novel and ATP-competitive inhibitor for AKT2 (IC50= 6 nM). It also has 28-fold and 20-fold selectivity over PKA kinase (IC50= 168 nM) and p70S6K (IC50= 120 nM),...

MSRP:

Was:

Now: $1,008 - $3,129

Choose Options Compare
Quick view

Biovision | MG-132 | 1703

A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex...

MSRP:

Was:

Now: $949 - $2,671

Choose Options Compare
Quick view

Biovision | NVP-BHG712 | 2464

A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks...

MSRP:

Was:

Now: $1,239 - $4,018

Choose Options Compare