Product Description
Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while weakly inhibiting smooth muscle myosin (IC₅₀ = 80 μM). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.
(-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPases.
Biovision | 2406 | (-)-Blebbistatin DataSheet
Alternate Name/Synonyms: 1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one; (S)-Blebbistatin
Appearance: Yellow solid
Formulation: N/A
CAS Number: 856925-71-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₆N₂O₂
Molecular Weight: 292.34
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~25 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A selective non-muscle myosin II ATPases inhibitor
MDL Number: MFCD08460907
PubChem CID: 5287792
SMILES: CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
InChi: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChi Key: LZAXPYOBKSJSEX-GOSISDBHSA-N