Product Description
AF/LE Purified Anti-Mouse CD366/Tim-3 Monoclonal Antibody | DL22112F | DLdevelop
Host: Rat
Synonyms: TIM3, TIMD3, HAVcr-2, TIMD-3
Reactivity: Mouse
Application: FCM, Block
Background: CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells) . Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
Concentration: 0.2 mg/mL
Conjugation: None (Purified antibody, Azide Free/Low endotoxin)
Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.
Clone: RMT3-23
Isotype: Rat IgG2a, κ