Euro
USD
British Pound
NULL
Product Description
Anti-Human IL-21 Monoclonal Antibody (PE Conjugated) | DL22176F | DLdevelop
Host: Mouse
Synonyms: Interleukin-21, IL-21, Za11
Reactivity: Human
Application: ICFCM
Background: Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Concentration: N/A
Conjugation: PE
Buffer: PBS with 0.05% Proclin300, 1% BSA
Clone: 3A3-N2
Isotype: Mouse IgG1, κ
