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Product Description
Purified Anti-Mouse CD40 Monoclonal Antibody | DL20438F | DLdevelop
Host: Rat
Synonyms: Tumor necrosis factor receptor superfamily member 5, Cd40, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, Tnfrsf5
Reactivity: Mouse
Application: FCM
Background: CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.
Concentration: 0.2 mg/mL
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Clone: FGK4.5/FGK45
Isotype: Rat IgG2a, κ
