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Product Description
SPTA1 Polyclonal Antibody | E-AB-19527 | Elabscience
Type: Polyclonal Antibody
Synonyms: Alpha I spectrin, EL 2, EL2, Elliptocytosis 2, Elliptocytosis2, Erythrocyte alpha spectrin, erythrocyte, Erythroid alpha spectrin, Erythroid alpha-spectrin, Erythroid spectrin alpha, HPP, HS3, Spectrin alpha chain, Spectrin alpha chain erythrocyte, Spectrin alpha erythrocytic 1, SPH3, SPTA 1, SPTA, SPTA1, SPTA1
Application: WB, IHC, ELISA
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cardiovascular, Signal transduction
Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
Concentration: 1.7 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human SPTA1
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: WB 1:500-1:2000, IHC 1:60-1:450, ELISA 1:5000-1:10000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 280 kDa
Molecular Weight(Observed): Refer to figures
