Product Description
FITC Anti-Mouse CD105 Antibody[MJ7/18] | E-AB-F1233C | Elabscience
Category: Flow Cytometry Antibody
Synonyms: Endoglin,END,Eng
Swissprot Code: Q63961
Application: FCM
Reactivity: Mouse
Host: Rat
Isotype: Rat IgG2a, κ
Reaserch Area: N/A
Background: CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.
Concentration: N/A
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Immunogen: N/A
Purification Method: N/A
Dilution: N/A
Clone: MJ7/18
Conjugation: FITC