Product Description
CHRD Polyclonal Antibody | E-AB-18617 | Elabscience
Type: Polyclonal Antibody
Synonyms: Chordin, chrd, CHRD, MGC133038, Shortgastrulation protein, SOG
Application: IHC, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Developmental Biology, Neuroscience, Stem Cells
Background: CHRD (Chordin) is a Protein Coding gene. Diseases associated with CHRD include Cornelia De Lange Syndrome. Among its related pathways are Mesodermal Commitment Pathway and TGF-beta signaling pathway (KEGG). GO annotations related to this gene include heparin binding and syndecan binding. An important paralog of this gene is CHRDL2.This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined.
Concentration: 0.8 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Fusion protein of human CHRD
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A