Euro
USD
British Pound
NULL
Product Description
NBR1 Monoclonal Antibody | E-AB-22148 | Elabscience
Type: Monoclonal Antibody
Synonyms: 1A1 3B, 1A13B, B box protein, Cell migration-inducing gene 19 protein, KIAA0049, M17S2, Membrane component chromosome 17 surface marker 2, Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125), MIG 19, MIG19, Migration inducing protein 19, NBR 1, Nbr1, NBR1, autophagy cargo receptor, NBR1, Neighbor of BRCA1 gene 1, Neighbor of BRCA1 gene 1 protein, Next to BRCA1 gene 1 protein, Ovarian carcinoma antigen CA125, Protein 1A1-3B
Application: IHC-p, IF
Reactivity: Human, Mouse, Rat
Host: Mouse
Isotype: IgG
Reserch Areas: Cancer, Cell Biology
Background: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Protein of NBR1
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification Method: Protein A purification
Dilution: IHC 1:50-300, IF 1:50-1:200
Clone: Clone:4C6
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A
