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Product Description
FGFR1 Polyclonal Antibody | E-AB-10320 | Elabscience
Type: Polyclonal Antibody
Synonyms: Basic fibroblast growth factor receptor 1, bFGF-R-1, BFGFR, CD331, CEK, FGFBR, FGFR 1, FGFR-1, FGFR1, FGFR1/PLAG1 fusion, FGFR1, fibroblast growth factor receptor 1, FLG, FLT-2, FLT2, Fms-like gene, Fms-like tyrosine kinase 2, fms-related tyrosine kinase 2, HBGFR, heparin-binding growth factor receptor, HH2, HRTFDS, hydroxyaryl-protein kinase, KAL2, N-SAM, OGD, Proto-oncogene c-Fgr
Application: IHC, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction
Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Concentration: 0.6 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant protein of human FGFR1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:50-1:300
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A
