Product Description
GJB6 Polyclonal Antibody | E-AB-12383 | Elabscience
Type: Polyclonal Antibody
Synonyms: Connexin 30, Connexin-30, Cx30, CXB6, DFNA3, DFNA3B, DFNB1B, ECTD2, ectodermal dysplasia 2, hidrotic (Clouston syndrome), ED2, EDH, Gap junction beta 6 protein, Gap junction beta-6 protein, gap junction protein, beta 6 (connexin 30), gap junction protein, beta 6, Gap junction protein, beta 6, 30kDa, GJB6, HED, HED2, NSRD1
Application: WB, IHC, ELISA
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Reserch Areas: Neuroscience, Signal Transduction
Background: Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
Concentration: 0.3 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human GJB6
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:25-1:100
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 30 kDa
Molecular Weight(Observed): N/A