Product Description
MYSM1 Polyclonal Antibody | E-AB-12793 | Elabscience
Type: Polyclonal Antibody
Synonyms: 2A-DUB, 2ADUB, Histone H2A deubiquitinase, Histone H2A deubiquitinase MYSM1, KIAA1915, Myb like SWIRM and MPN domains 1, Myb like, SWIRM and MPN domain containing protein, Myb like, SWIRM and MPN domains 1, Myb-like, Myb-like, SWIRM and MPN domains 1, MYSM 1, mysm1, MYSM1 Myb-like, SWIRM and MPN domains 1, MYSM1, RP4-592A1.1, SWIRM and MPN domain-containing protein 1
Application: IHC, ELISA
Reactivity: Human
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Epigenetics and Nuclear Signaling
Background: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones
Concentration: 0.5 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human MYSM1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:50-1:200
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A