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Product Description
Phospho-MDM2(S166) Polyclonal Antibody | E-AB-68070 | Elabscience
Type: Phosphorylated antibody
Synonyms: MDM2, ACTFS, HDMX, hdm2
Application: WB, IF
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Background: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Method: Affinity purification
Dilution: WB 1:500-1:1000 IF 1:50-1:100
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 11-14 kDa/24-55 kDa
Molecular Weight(Observed): 95 kDa
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