Product Description
ATXN3 Polyclonal Antibody | E-AB-40246 | Elabscience
Type: Polyclonal Antibody
Synonyms: AT3, Ataxin 3, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant ref, Ataxin-3, ATX3, EC 3.4.22, JOS, Machado Joseph disease, MJD, Olivopontocerebellar ataxia 3, OTTHUMP00000221583, Rsca3, Spinocerebellar ataxia type 3 protein
Application: WB, IHC
Reactivity: Human
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience
Background: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Concentration: 2 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Human Ataxin-3 protien
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 41 kDa
Molecular Weight(Observed): 41 kDa, 22 kDa