Product Description
PTCH1 Polyclonal Antibody | E-AB-10571 | Elabscience
Type: Polyclonal Antibody
Synonyms: PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11
Application: WB, IHC, ELISA
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cell Biology, Neuroscience, Stem Cells
Background: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
Concentration: 0.5 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant protein of human PTCH1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:50-1:200
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 161 kDa
Molecular Weight(Observed): N/A