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Product Description
PCSK9/Proprotein Convertase 9 | E21-A83 | EnoGene
Short Description: Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a 6His tag at the C-terminus.
Shipping: Dry Ice/ice packs
Formulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20%Glycerol, pH 7.4.
Storage: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Reconstitution: N/A
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Background: Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2) , and play a role in the neural development.
Species: Human
Expression System: Human cells
