Product Description
Anti- ERBB4 Antibody | FNab02829 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Immunogen: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
synonyms: HER4
Molecular weight (observed) : 180 kDa
Reactivity Species: Mouse, Rat
Tested Application: ELISA, IHC
Recomended Dillution : WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Research Area: Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology