Product Description
Anti- CBFA2T3 Antibody | FNab01316 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097) . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097) . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity) . Plays a role in granulocyte differentiation (PubMed:15231665) . Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486) .
Immunogen: core-binding factor, runt domain, alpha subunit 2; translocated to, 3
synonyms: MTG16, MTGR2, ZMYND4
Molecular weight (observed) : 62-65kd
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC
Recomended Dillution : WB: 1:500-1:2000
Research Area: Metabolism