Product Description
Anti- RRP8 Antibody | FNab07501 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD (+) /NADP (+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Immunogen: ribosomal RNA processing 8, methyltransferase, homolog (yeast)
synonyms: KIAA0409, NML
Molecular weight (observed) : 51 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IF, IHC
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Research Area: Epigenetics, Metabolism