Product Description
Anti- USP44 Antibody | FNab09334 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) . Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Immunogen: ubiquitin specific peptidase 44
synonyms: Deubiquitinating enzyme 44, DKFZp434D0127, FLJ14528, Ubiquitin thiolesterase 44, USP44
Molecular weight (observed) : 81 kDa
Reactivity Species: Human
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:5000
Research Area: Epigenetics, Metabolism