Product Description
Anti- CTNNA1 Antibody | FNab02056 | FineTest
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 0A11
Isotype: IgG1
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Immunogen: catenin (cadherin-associated protein), alpha 1, 102kDa
synonyms: Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1
Molecular weight (observed) : 95-100 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC, IP
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:50-1:1000
Research Area: cancer, Signal Transduction, stem cells