Product Description
Anti- HNRNPC Antibody | FNab03949 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621) . Specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm (6) A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671) . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621) .
Immunogen: heterogeneous nuclear ribonucleoprotein C (C1/C2)
synonyms: HNRPC
Molecular weight (observed) : 32 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Research Area: Neuroscience, Metabolism