Product Description
Anti- ZCCHC6 Antibody | FNab09611 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly (A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299) . Involved in microRNA (miRNA) -induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299) . Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7) . Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984) . Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
Immunogen: zinc finger, CCHC domain containing 6
synonyms: DKFZp666B142, DKFZp686C11112, DKFZp686F119, DKFZp686I1269, HS2, KIAA1711, PAPD6, Terminal uridylyltransferase 7, TUT7, TUTase 7, ZCCHC6
Molecular weight (observed) : 171 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:500-1:5000; IP: 1:500-1:5000
Research Area: N/A