Product Description
Anti- KANK2 Antibody | FNab04465 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081) . May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500) . May be involved in promotion of cell proliferation (By similarity) .
Immunogen: KN motif and ankyrin repeat domains 2
synonyms: ANKRD25, KIAA1518, MXRA3, SIP
Molecular weight (observed) : 95 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC, IF
Recomended Dillution : WB: 1:500-1:2000; IF: 1:20-1:200
Research Area: Signal Transduction