Product Description
Anti- LGR6 Antibody | FNab04766 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
Immunogen: leucine-rich repeat-containing G protein-coupled receptor 6
synonyms: FLJ14471, GPCR, LGR6, VTS20631
Molecular weight (observed) : 104 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC
Recomended Dillution : WB: 1:200-1:1000; IHC: 1:20-1:200
Research Area: Signal Transduction