Product Description
Anti- LRRC8D Antibody | FNab04862 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) ; channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658) . LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471) . Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309) .
Immunogen: leucine rich repeat containing 8 family, member D
synonyms: LRRC5
Molecular weight (observed) : 98-120 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IF, IHC
Recomended Dillution : WB: 1:500-1:2000
Research Area: Signal Transduction