Product Description
Anti- SHP2 Antibody | FNab07854 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: PTPN11 (protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism (PMID:19017799) . Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions (PMID:21576358) . Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC) . It has 3 isoforms produced by alternative splicing.
Immunogen: protein tyrosine phosphatase, non-receptor type 11
synonyms: BPTP3, CFC, NS1, PTP 1D, PTP 2C, PTP2C, PTPN11, SH PTP2, SH PTP3, SHP 2, SHP2, SHPTP2
Molecular weight (observed) : 68kDa, 53kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IF, IP
Recomended Dillution : WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100
Research Area: Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology