Product Description
Anti- uPA Antibody | FNab09267 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: PLAU (Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1 (PAI-1), which is stored in the extracellular matrix bound to vitronectin (PMID:9665342) .It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder (QPD) .
Immunogen: plasminogen activator, urokinase
synonyms: ATF, PLAU, U plasminogen activator, uPA, URK
Molecular weight (observed) : 54 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:1000; IHC:1:20-1:200;IF: 1:20-1:200; IP: 1:500-1:2000
Research Area: Immunology, Cardiovascular, Signal Transduction