Product Description
Anti- uPAR Antibody | FNab09268 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)
Immunogen: plasminogen activator, urokinase receptor
synonyms: CD87, MO3, PLAUR, U PAR, UPAR, URKR
Molecular weight (observed) : 37-70 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC, IP, IF
Recomended Dillution : WB: 1:200-1:2000; IP: 1:200-1:1000
Research Area: Immunology, Cardiovascular, Signal Transduction