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Product Description
Recombinant Human IGFBP-4 Protein (C-His Tag) | PH0125M1 | Leading Biology
Short Description: Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.
Product Type: Cytokine
Form: lyophilized
Purity: Greater than 95% by SDS-PAGE
Storage: -70°C
Buffer: 0.2 μm filtered PBS, pH7.4
