Product Description
ATXN1 Antibody (S776) [APG03177G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
Cellular Localisation: Cytoplasm. Nucleus Note=Colocalizes with USP7 in the nucleus
Molecular Weight: 86923
Clone: Polyclonal
Gene Name: ATXN1
Gene ID: 6310
Function: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249) . In concert with CIC and ATXN1L, involved in brain development (By similarity) .
Summary: Tissue Location: Widely expressed throughout the body.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IF, WB
Dilution: WB--1:2000
Synonyms: Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1