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![NR2C2 Antibody (C-term) [APR31818G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/872063/1164130/logo__92149.1659788186__00344.1659868319.png?c=2 "NR2C2 Antibody (C-term) [APR31818G]"){kind=logo}
![NR2C2 Antibody (C-term) [APR31818G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/872063/1164130/logo__92149.1659788186__00344.1659868319.png?c=2 "NR2C2 Antibody (C-term) [APR31818G]"){kind=logo}
Product Description
NR2C2 Antibody (C-term) [APR31818G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This NR2C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-466 amino acids from the C-terminal region of human NR2C2.
Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:15302918}
Molecular Weight: 65414
Clone: Polyclonal
Gene Name: NR2C2
Gene ID: 7182
Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity) . Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IF, WB
Dilution: WB--1:1000 IF--1:10~50
Synonyms: Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, NR2C2, TAK1, TR4
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