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Product Description
MBD3 Antibody (C-term) [AMM22154G] | Leading Biology
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: H
Specificity: Purified His-tagged MBD3 protein was used to produced this monoclonal antibody.
Cellular Localisation: Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes
Molecular Weight: 32844
Clone: Monoclonal
Gene Name: MBD3
Gene ID: 53615
Function: Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384) . Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro) . Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175) . Recruits histone deacetylases and DNA methyltransferases.
Summary: N/A
Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, MBD3
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