Product Description
C12orf48 Antibody (C-term) [APR30544G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This C12orf48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 522-550 amino acids from the C-terminal region of human C12orf48.
Cellular Localisation: Cytoplasm. Nucleus Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA
Molecular Weight: 65054
Clone: Polyclonal
Gene Name: PARPBP
Gene ID: 55010
Function: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly (A) homopolymers. Positively regulate the poly (ADP-ribosyl) ation activity of PARP1; however such function may be indirect.
Summary: Tissue Location: Restricted to testis. Overexpressed in multiple cancer cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:1000 FC--1:10~50
Synonyms: PCNA-interacting partner, PARI, PARP-1 binding protein, PARP1-binding protein, PARPBP, PARPBP, C12orf48, PARI