Product Description
CLCN7 Antibody (C-term) [APR30859G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This CLCN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-720 amino acids from the C-terminal region of human CLCN7.
Cellular Localisation: Lysosome membrane; Multi-pass membrane protein
Molecular Weight: 88679
Clone: Polyclonal
Gene Name: CLCN7 (HGNC:2025)
Gene ID: 1186
Function: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911) . Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284) . The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity) . The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity) .
Summary: Tissue Location: Brain and kidney..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, IF
Dilution: WB--1:1000
Synonyms: H (+) /Cl (-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7, CLCN7