Product Description
DEF Antibody (N-term) [APR03621G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, Ha, M
Specificity: This DEF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human DEF.
Cellular Localisation: Nucleus, nucleolus
Molecular Weight: 87055
Clone: Polyclonal
Gene Name: UTP25 (HGNC:28440)
Gene ID: 27042
Function: Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity) . Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851) . Also involved in the sympathetic neuronal development (By similarity) . Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329) .
Summary: Tissue Location: Expressed in colon..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, IF, WB, FC
Dilution: WB--1:2000
Synonyms: Digestive organ expansion factor homolog, DIEXF, C1orf107, DEF