Product Description
DNASE1 Antibody (Center) [APR07606G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This DNASE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 87-121 amino acids from the Central region of human DNASE1.
Cellular Localisation: Secreted. Zymogen granule. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope
Molecular Weight: 31434
Clone: Polyclonal
Gene Name: DNASE1 (HGNC:2956)
Gene ID: 1773
Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032) . Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity) . Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278) . Binds specifically to G-actin and blocks actin polymerization (By similarity) . Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity) . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity) . Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity) .
Summary: Tissue Location: Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: IHC-P-Leica, WB
Dilution: IHC-P-Leica--1:500 WB--1:1000
Synonyms: Deoxyribonuclease-1, Deoxyribonuclease I, DNase I, Dornase alfa, DNASE1, DNL1, DRNI