Product Description
MEPE Antibody (N-term) [APR30942G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MEPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human MEPE.
Cellular Localisation: Secreted, extracellular space, extracellular matrix
Molecular Weight: 58419
Clone: Polyclonal
Gene Name: MEPE
Gene ID: 56955
Function: Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008) . Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095) . Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity) . Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070) .
Summary: Tissue Location: Expressed by osteoblasts (PubMed:10945470, PubMed:11414762, PubMed:15108058) . Expressed by stem cells in dental pulp (PubMed:15153459) . Expressed by mesenchymal cells in dental papilla and dental pulp (PubMed:18547474, PubMed:22341070) . Expressed in teeth, specifically in decidious dentin (PubMed:20581062) . Expressed in ondotoblasts (PubMed:12489176) . Expressed in salivary glands (PubMed:15329369) . Secreted from oncogenic hypophosphatemic tumors (PubMed:11414762) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Matrix extracellular phosphoglycoprotein, Osteoblast/osteocyte factor 45, OF45, MEPE