Product Description
PRKX Antibody (C-term) [APR14381G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This PRKX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-343 amino acids from the C-terminal region of human PRKX.
Cellular Localisation: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation
Molecular Weight: 40896
Clone: Polyclonal
Gene Name: PRKX
Gene ID: 5613
Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular- like structure formation.
Summary: Tissue Location: Widely expressed (at protein level) . Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P
Dilution: IHC-P--1:100~500
Synonyms: cAMP-dependent protein kinase catalytic subunit PRKX, PrKX, Protein kinase X, Protein kinase X-linked, Serine/threonine-protein kinase PRKX, Protein kinase PKX1, PRKX, PKX1