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![TRIM56Antibody (C-term) [APR30849G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/871094/1163161/logo__92149.1659788186__32452.1659867134.png?c=2 "TRIM56Antibody (C-term) [APR30849G]"){kind=logo}
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Product Description
TRIM56Antibody (C-term) [APR30849G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TRIM56 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 727-755 amino acids from the C-terminal region of human TRIM56.
Cellular Localisation: Cytoplasm.
Molecular Weight: 81488
Clone: Polyclonal
Gene Name: TRIM56
Gene ID: 81844
Function: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118) . In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'- linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity) . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA) -induced expression of IFNB1 and interferon- stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3- mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160) .
Summary: Tissue Location: Widely expressed (at protein level) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: E3 ubiquitin-protein ligase TRIM56, 632-, RING finger protein 109, Tripartite motif-containing protein 56, TRIM56, RNF109
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